Long-term metformin adherence in the Diabetes Prevention Program Outcomes Study.

ABSTRACT:

Introduction

To investigate long-term metformin adherence in the Diabetes Prevention Program Outcomes Study (DPPOS) by examining: (1) predictors of long-term adherence to study metformin and (2) whether metformin adherence was associated with incident type 2 diabetes.

Research design and methods

DPPOS was an open-label continuation of the randomized clinical trial (Diabetes Prevention Program (DPP)) in which eligible participants randomized to the metformin group were offered study metformin and followed over 11 years. A brief structured adherence interview was administered semiannually. Metformin adherence was assessed by pill counts. Predictors of metformin adherence were examined in multivariate regression models. Incident diabetes associated with metformin adherence and

SUBMITTER: Walker EA 

PROVIDER: S-EPMC7539607 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature