The precious fluorine on the ring: fluorine NMR for biological systems.

ABSTRACT: The fluorine-19 nucleus was recognized early to harbor exceptional properties for NMR spectroscopy. With 100% natural abundance, a high gyromagnetic ratio (83% sensitivity compared to ¹H), a chemical shift that is extremely sensitive to its surroundings and near total absence in biological systems, it was destined to become a favored NMR probe, decorating small and large molecules. However, after early excitement, where uptake of fluorinated aromatic amino acids was explored in a series of animal studies, ¹⁹F-NMR lost popularity, especially in large molecular weight systems, due to chemical shift anisotropy (CSA) induced line broadening at high magnetic fields. Recently, two orthogonal approaches, (i) CF₃ labeling and (ii) aromatic ¹⁹F-¹³

SUBMITTER: Boeszoermenyi A 

PROVIDER: S-EPMC7539674 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature