Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association.

ABSTRACT: Unique features of sensory neuron subtypes are manifest by their distinct physiological and pathophysiological functions. Using patch-clamp electrophysiology, Ca²⁺ imaging, calcitonin gene-related peptide release assay from tissues, protein biochemistry approaches, and behavioral physiology on pain models, this study demonstrates the diversity of sensory neuron pathophysiology is due in part to subtype-dependent sensitization of TRPV1 and TRPA1. Differential sensitization is influenced by distinct expression of inflammatory mediators, such as prostaglandin E₂ (PGE₂), bradykinin (BK), and nerve growth factor (NGF) as well as multiple kinases, including protein kinase A (PKA) and C (PKC). However, the co-expression and interaction of TRPA1 with TRPV1 proved t

SUBMITTER: Patil MJ 

PROVIDER: S-EPMC7539696 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature