CpG methylation signature defines human temporal lobe epilepsy and predicts drug-resistant.

ABSTRACT:

Aims

Temporal lobe epilepsy (TLE) is the most common focal epilepsy syndrome in adults and frequently develops drug resistance. Studies have investigated the value of peripheral DNA methylation signature as molecular biomarker for diagnosis or prognosis. We aimed to explore methylation biomarkers for TLE diagnosis and pharmacoresistance prediction.

Methods

We initially conducted genome-wide DNA methylation profiling in TLE patients, and then selected candidate CpGs in training cohort and validated in another independent cohort by employing machine learning algorithms. Furthermore, nomogram comprising DNA methylation and clinicopathological data was generated to predict the drug response in the entire patient cohort. Lastly, bioinformatics analysis for CpG-associated genes wa

SUBMITTER: Xiao W 

PROVIDER: S-EPMC7539843 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature