Meta-analysis of the risk of autoimmune thyroiditis, Guillain-Barre syndrome, and inflammatory bowel disease following vaccination with AS04-adjuvanted human papillomavirus 16/18 vaccine.

ABSTRACT:

Purpose

To assess the risk of three autoimmune diseases - autoimmune thyroiditis (AIT), Guillain-Barré syndrome (GBS), and inflammatory bowel disease (IBD) - in females following AS04-HPV-16/18 vaccination.

Methods

This meta-analysis included data from 18 randomized controlled trials, one cluster-randomized trial, two large observational retrospective cohort studies, and one case-control study. Following vaccination, a risk window of 2 years was defined for AIT and IBD and 42 days for GBS. Odds ratios (ORs) were estimated using three methods: meta-analysis inverse-variance with continuity correction (primary analysis), pooled estimate, and beta-binomial regression.

Results

In all studies apart from the case-control study, 154 398 exposed and 1 504 322 non-exposed subj

SUBMITTER: Rosillon D 

PROVIDER: S-EPMC7539912 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature