Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency.

ABSTRACT:

Problem

Premature ovarian insufficiency (POI) imposes great challenge on female reproduction. Whether immune disturbance in ovarian environment was implicated in POI remains unclear. We aimed to characterize the cytokine profile in follicular fluid (FF) and paired serum in patients with biochemical POI (bPOI).

Method of study

Multiplex immunoassay containing 45 cytokines was performed for individual FF and paired serum samples from 35 bPOI patients and 37 matched controls. Cytokine profiles were compared between the two groups and cytokines correlated to ovarian reserve, and the rates of day-3 good-quality embryos were further analyzed.

Results

In FF, significantly elevated level of chemokines MIP-1α (P = .043), CXCL8 (P = .024), IP-10 (P = .041), and eotaxin-1 (P = .

SUBMITTER: Liu P 

PROVIDER: S-EPMC7539985 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature