House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

ABSTRACT:

Background

House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross-sectional and limited to a single exposure measurement.

Objective

We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age.

Methods

We used data of 854 participants of the prospective Dutch PIAMA birth cohort study with house dust endotoxin measurements at 3 months and/or 5-6 years and data on asthma and/or allergic sensitization from at least one of 11 follow-ups until age 17. We assessed overall and age-specific associations of the prevalence of

SUBMITTER: Gehring U 

PROVIDER: S-EPMC7540017 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature