Impaired Hematological Status Increases the Risk of Mortality among HIV-Infected Adults Initiating Antiretroviral Therapy in Tanzania.

ABSTRACT:

Background

Hematological status may predict HIV disease progression and mortality among adults initiating highly active antiretroviral therapy (HAART).

Objectives

We aimed to examine the relation of anemia and iron status at HAART initiation with survival and morbidity outcomes.

Methods

We conducted a case-cohort study of 570 HIV-infected adults initiating HAART who were enrolled in a trial of multivitamins in Tanzania. Hemoglobin, serum ferritin, and hepcidin concentrations were assessed at HAART initiation and participants were followed up monthly. We adjusted serum ferritin for inflammation using a regression correction method to characterize hematological status. Cox proportional hazards models were used to estimate HRs for mortality and incident clinical outcomes

SUBMITTER: Noor RA 

PROVIDER: S-EPMC7540061 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature