LncRNA-PVT1 aggravates severe acute pancreatitis by promoting autophagy via the miR-30a-5p/Beclin-1 axis.

ABSTRACT: Severe acute pancreatitis (SAP) is a serious abdominal disease associated with increased morbidity and high mortality rates. The initial pancreatic injury and inflammatory response, which begins within acinar cells, play vital roles in promoting SAP severity. Previous studies have indicated that overactivated autophagy in acinar cells increases the risk of SAP. Autophagy is affected by various signaling pathways, partially through long noncoding RNA (lncRNA)-PVT1. However, few studies have focused on the effect of lncRNA on autophagy in pancreatitis. Our results demonstrate that sodium taurocholate (STC) induces abnormal activation of the autophagic response in pancreatic acinar cells in vitro and in vivo. The lncRNA-PVT1 level was significantly upregulated in this process an

SUBMITTER: Hu F 

PROVIDER: S-EPMC7540137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature