Identification and validation of the prognostic value of immune-related genes in non-small cell lung cancer.

ABSTRACT: Immune-related genes play a significant role in predicting the overall survival and monitoring the status of the cancer immune microenvironment. The aim of this research study was to identify differentially expressed immune-related genes (DEIRGs) and establish a Cox prediction model for the evaluation of prognosis in patients with non-small cell lung cancer (NSCLC). Transcription expression data, immune gene data, and tumor transcription factor data from The Cancer Genome Atlas (TCGA), the Immunology Database and Analysis Portal, and the Cistrome Cancer database were analyzed to detect differentially expressed genes (DEGs), DEIRGs, and differentially expressed transcription factors (DETFs). Multivariate Cox regression analysis was used to obtain potential DEIRGs as independent prognostic f

SUBMITTER: Li R 

PROVIDER: S-EPMC7540139 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature