Phenothiazine-Biaryl-Containing Fluorescent RGD Peptides.

ABSTRACT: Cyclic RGD peptides are well-known ligands of integrins. The integrins α_V β₃ and α₅ β₁ are involved in angiogenesis, and integrin α_V β₃ is abundantly present on cancer cells, thus representing a therapeutic target. Hence, synthetic and biophysical studies continuously are being directed towards the understanding of ligand-integrin interaction. In this context, the development of versatile synthetic strategies to obtain fluorescent building blocks that can add molecular diversity and modular spectral characteristics while not compromising binding affinity or selectivity is a relevant task. An on-resin intramolecular Suzuki-Miyaura cross-coupling (SMC) between l- or d-7-bromotryptophan (7BrTrp) and a phenothiazine (Ptz) boroni

SUBMITTER: Ghabraie E 

PROVIDER: S-EPMC7540173 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature