Greater variability in lipid measurements associated with cardiovascular disease and mortality: A 10-year diabetes cohort study.

ABSTRACT:

Aim

To examine the associations between variability in lipids and the risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes based on low-density lipoprotein-cholesterol (LDL-C), the total cholesterol (TC) to high-density lipoprotein-cholesterol (HDL-C) ratio and triglycerides (TG).

Materials and methods

A retrospective cohort study included 125 047 primary care patients with type 2 diabetes aged 45-84 years without CVD during 2008-2012. The variability of LDL-C, TC to HDL-C and TG was determined using the standard deviation of variables in a mixed effects model to minimize regression dilution bias. The associations between variability in lipids and CVD and mortality risk were assessed by Cox regression. Subgroup analyses based on patients' basel

SUBMITTER: Wan EYF 

PROVIDER: S-EPMC7540339 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature