Surgery for multiple endocrine neoplasia type 1-related insulinoma: long-term outcomes in a large international cohort.

ABSTRACT:

Background

Insulinomas are found in 10-15 per cent of patients with multiple endocrine neoplasia type 1 (MEN1) and lead to life-threatening hypoglycaemia. Surgical outcome and the optimal surgical strategy for MEN1-related insulinoma are unknown.

Methods

Patients with MEN1-related insulinomas were identified in 46 centres in Europe and North America between 1990 and 2016. Insulinomas were considered localized if the lesion was in the pancreatic head or body/tail. Patients with pancreatic neuroendocrine tumours throughout the pancreas were suspected of having multifocal insulinoma. The primary outcome was postoperative hypoglycaemia, defined as persistent hypoglycaemia, or recurrent hypoglycaemia caused by a new insulinoma or insulin-producing liver metastases. Hypoglycaemia-

SUBMITTER: van Beek DJ 

PROVIDER: S-EPMC7540387 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature