Four-Dimensional Deoxyribonucleic Acid-Gold Nanoparticle Assemblies.

ABSTRACT: Organization of gold nanoobjects by oligonucleotides has resulted in many three-dimensional colloidal assemblies with diverse size, shape, and complexity; nonetheless, autonomous and temporal control during formation remains challenging. In contrast, living systems temporally and spatially self-regulate formation of functional structures by internally orchestrating assembly and disassembly kinetics of dissipative biomacromolecular networks. We present a novel approach for fabricating four-dimensional gold nanostructures by adding an additional dimension: time. The dissipative character of our system is achieved using exonuclease III digestion of deoxyribonucleic acid (DNA) fuel as an energy-dissipating pathway. Temporal control over amorphous clusters composed of spherical gold nanoparticl

SUBMITTER: Luo M 

PROVIDER: S-EPMC7540408 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature