Elucidation of the Intersystem Crossing Mechanism in a Helical BODIPY for Low-Dose Photodynamic Therapy.

ABSTRACT: Intersystem crossing (ISC) of triplet photosensitizers is a vital process for fundamental photochemistry and photodynamic therapy (PDT). Herein, we report the co-existence of efficient ISC and long triplet excited lifetime in a heavy atom-free bodipy helicene molecule. Via theoretical computation and time-resolved EPR spectroscopy, we confirmed that the ISC of the bodipy results from its twisted molecular structure and reduced symmetry. The twisted bodipy shows intense long wavelength absorption (ϵ=1.76×10⁵  m^-1  cm^-1 at 630 nm), satisfactory triplet quantum yield (Φ_T =52 %), and long-lived triplet state (τ_T =492 μs), leading to unprecedented performance as a triplet photosensitizer for PDT. Moreover, nanoparticles constructed with suc

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7540422 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature