Environment-Wide Association Study (Eⁿ WAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study.

ABSTRACT: A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a te

SUBMITTER: Amiri M 

PROVIDER: S-EPMC7540497 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature