The role of cyclin D1 and Ki-67 in the development and prognostication of thin melanoma.

ABSTRACT:

Aims

Despite their low individual metastatic potential, thin melanomas (≤1 mm Breslow thickness) contribute significantly to melanoma mortality overall. Therefore, identification of prognostic biomarkers is particularly important in this subgroup of melanoma. Prompted by preclinical results, we investigated cyclin D1 protein and Ki-67 expression in in-situ, metastatic and non-metastatic thin melanomas.

Methods and results

Immunohistochemistry was performed on 112 melanoma specimens, comprising 22 in situ, 48 non-metastatic and 42 metastatic thin melanomas. Overall, epidermal and dermal cyclin D1 and Ki-67 expression were semiquantitatively evaluated by three independent investigators and compared between groups. Epidermal Ki-67 expression did not differ statistically in in-s

SUBMITTER: Kaufmann C 

PROVIDER: S-EPMC7540531 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature