Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.

ABSTRACT: The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.

SUBMITTER: Scupakova K 

PROVIDER: S-EPMC7540554 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature