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Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.

ABSTRACT: The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.

SUBMITTER: Scupakova K 

PROVIDER: S-EPMC7540554 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.

Ščupáková Klára K   Dewez Frédéric F   Walch Axel K AK   Heeren Ron M A RMA   Balluff Benjamin B  

Angewandte Chemie (International ed. in English) 20200817 40

The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features. ...[more]