Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats.

ABSTRACT: Social play is a highly rewarding and motivated behaviour displayed by juveniles of many mammalian species. We hypothesized that the orexin/hypocretin (ORX) system is involved in the expression of juvenile social play behaviour because this system is interconnected with brain regions that comprise the social behaviour and mesocorticolimbic reward networks. We found that exposure to social play increased recruitment of ORX-A neurons in juvenile rats. Furthermore, central administration of ORX-A decreased social play duration, while central blockade of ORX-1 receptors differentially altered social play duration in juvenile rats with low versus high baseline levels of social play (increasing social play in low baseline social play individuals and decreasing social play in high baseline social

SUBMITTER: Reppucci CJ 

PROVIDER: S-EPMC7540609 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature