Safe, selective histopathological examination of gallbladder specimens: a systematic review.

ABSTRACT:

Background

Routine histopathological examination after cholecystectomy is costly, but the prevalence of unsuspected gallbladder cancer (incidental GBC) is low. This study determined whether selective histopathological examination is safe.

Methods

A comprehensive search of PubMed, Embase, Web of Science and the Cochrane Library was performed. Pooled incidences of incidental and truly incidental GBC (GBC detected during histopathological examination without preoperative or intraoperative suspicion) were estimated using a random-effects model. The clinical consequences of truly incidental GBC were assessed.

Results

Seventy-three studies (232 155 patients) were included. In low-incidence countries, the pooled incidence was 0·32 (95 per cent c.i. 0·25 to 0·42) per cent for

SUBMITTER: Bastiaenen VP 

PROVIDER: S-EPMC7540681 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature