Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy.

ABSTRACT: Personalised cancer treatment depends on identification of therapeutically relevant biological subgroups of patients for assessing effect of treatment and to discover new therapeutic options. By analyses in heterogeneous patient populations, the effects may be lost in noise. Squamous cell carcinoma of the lung is a major killer worldwide. Despite recent advances, mortality is high and response to therapies varies greatly from patient to patient. Target search in biologically relevant subgroups may identify treatment options not so far discovered. A total of 198 patients undergoing surgery for squamous cell carcinomas of the lung were included in the study. The tumours were analysed for copy number alterations (n = 152) and gene expression from tumour (n = 188) and normal lung (n = 21), wit

SUBMITTER: Haakensen VD 

PROVIDER: S-EPMC7540694 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature