Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain.

ABSTRACT: In Alzheimer's disease, amyloid plaque formation is associated with the focal death of oligodendrocytes and soluble amyloid β impairs the survival of oligodendrocytes in vitro. However, the response of oligodendrocyte progenitor cells (OPCs) to early amyloid pathology remains unclear. To explore this, we performed a histological, electrophysiological, and behavioral characterization of transgenic mice expressing a pathological form of human amyloid precursor protein (APP), containing three single point mutations associated with the development of familial Alzheimer's disease (PDGFB-APP^Sw.Ind , also known as J20 mice). PDGFB-APP^Sw.Ind transgenic mice had impaired survival from weaning, were hyperactive by 2 months of age, and developed amyloid plaques by 6 months of ag

SUBMITTER: Ferreira S 

PROVIDER: S-EPMC7540704 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature