Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.

ABSTRACT: Intestinal health relies on the immunosuppressive activity of CD4⁺ regulatory T (T_reg) cells¹. Expression of the transcription factor Foxp3 defines this lineage, and can be induced extrathymically by dietary or commensal-derived antigens in a process assisted by a Foxp3 enhancer known as conserved non-coding sequence 1 (CNS1)^2-4. Products of microbial fermentation including butyrate facilitate the generation of peripherally induced T_reg (pT_reg) cells^5-7, indicating that metabolites shape the composition of the colonic immune cell population. In addition to dietary components, bacteria modify host-derived molecules, generating a number of biologically active substances. This is epitomized by the bacterial transform

SUBMITTER: Campbell C 

PROVIDER: S-EPMC7540721 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature