Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19.

ABSTRACT: In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.

SUBMITTER: Rajendaran S 

PROVIDER: S-EPMC7540766 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature