Monastrol derivatives: in silico and in vitro cytotoxicity assessments.

ABSTRACT:

Background and purpose

Cancer is the leading cause of death in today's world, therefore the efforts to achieve anticancer drugs with higher potency and fewer side effects have always been conducted by researchers in the field of pharmaceutical chemistry.Monastrol, a cytotoxic small molecule, from dihydropyrimidinone scaffold, is an inhibitor of the kinesin-5 protein. So, efforts to identify more derivatives of this molecule have been of interest.

Experimental approach

Some of monastrol's analogs as Eg5 inhibitors with different substitution patterns were analyzed, synthesized, and their cytotoxic effects were evaluated on MCF-7 and HeLa cancerous cells in vitro using the MTT assay. The structure-activity relationship (SAR) was studied in silico by molecular doc

SUBMITTER: Bidram Z 

PROVIDER: S-EPMC7540817 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature