Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease.

ABSTRACT: Cognitive impairment in Alzheimer's disease (AD) is associated with dysregulation of the RNA and protein expression profiles in the brain. Recent studies have highlighted the importance of RNA post-transcriptional regulation (epitranscriptomics) in higher order brain functions. Specifically, N6-methyladenosine (m6A), which controls RNA stability, splicing, translation and trafficking, plays an important role in learning and memory. This raises the question of whether m6A signaling is perturbed in AD. To address this, we investigated the expression profile of known m6A-regulatory genes using a public RNA-seq dataset and identified a subset of genes which were significantly dysregulated in the human AD brain. Among these, genes encoding the m6A methyltransferase, METTL3, and a

SUBMITTER: Huang H 

PROVIDER: S-EPMC7540926 | biostudies-literature | 2020 Sep/Oct

REPOSITORIES: biostudies-literature