Rhesus macaques as a tractable physiological model of human ageing.

ABSTRACT: Research in the basic biology of ageing is increasingly identifying mechanisms and modifiers of ageing in short-lived organisms such as worms and mice. The ultimate goal of such work is to improve human health, particularly in the growing segment of the population surviving into old age. Thus far, few interventions have robustly transcended species boundaries in the laboratory, suggesting that changes in approach are needed to avoid costly failures in translational human research. In this review, we discuss both well-established and alternative model organisms for ageing research and outline how research in nonhuman primates is sorely needed, first, to translate findings from short-lived organisms to humans, and second, to understand key aspects of ageing that are unique to primate biology

SUBMITTER: Chiou KL 

PROVIDER: S-EPMC7540946 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature