Effect of malignant-associated pleural effusion on endothelial viability, motility and angiogenesis in lung cancer.

ABSTRACT: Malignant pleural effusion (MPE) and paramalignant pleural effusion (PPE) remain debilitating complications in lung cancer patients with poor prognosis and limited treatment options. The role of vascular endothelial cells has not been explored in the pleural environment of lung cancer. By integrating MPE and PPE as malignant-associated pleural fluid (MAPF), the current study aimed to evaluate the effect of MAPF on cell proliferation, migration and angiogenesis of HUVEC. First, increased capillaries were identified in the subpleural layer of lung adenocarcinoma. Compatible with pathological observations, the ubiquitous elevation of HUVEC survival was identified in MAPF culture regardless of the underlying cancer type, the driver gene mutation, prior treatments and evidence of malignant cell

SUBMITTER: Changchien CY 

PROVIDER: S-EPMC7541005 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature