Delayed initiation of adjuvant chemotherapy in older women with breast cancer.

ABSTRACT:

Background

Adjuvant chemotherapy benefits early-stage breast cancer (BC) patients. Older women receive guideline-adherent treatment less frequently and experience treatment delays more frequently. We evaluated factors associated with delaying adjuvant chemotherapy and the delays' survival impact in a large population-based cohort of elderly BC patients.

Methods

Patients age >66 years diagnosed 2001-2015 with localized or regional BC were identified in the SEER-Medicare and Texas Cancer Registry-Medicare databases. Time from surgery to chemotherapy (TTC) was categorized into four groups: 0-30, 31-60, 61-90, and >90 days. We identified predictors of delays, estimated overall (OS) and BC-specific (BCSS) survival, and determined the association between TTC and outcome adjusting

SUBMITTER: Smith-Graziani D 

PROVIDER: S-EPMC7541132 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature