Circulating immune cell dynamics in patients with triple negative breast cancer treated with neoadjuvant chemotherapy.

ABSTRACT:

Background

Lymphopenia has been associated with inferior cancer outcomes, but there is limited data in breast cancer. We describe the effects of neoadjuvant chemotherapy on circulating immune cells and its association with pathological complete response (pCR) rates in triple negative breast cancer (TNBC).

Methods

We constructed a database of patients with early stage TNBC treated with neoadjuvant chemotherapy. Circulating lymphocytes and monocytes were assessed before and after neoadjuvant chemotherapy. These were correlated with pCR rates and disease-free survival (DFS) using Fisher's exact test, logistic regression, and the log-rank test.

Results

From 2000 to 2015, we identified 95 eligible patients. Median age was 50; 29 (31%) were treated with platinum-containing

SUBMITTER: Talamantes S 

PROVIDER: S-EPMC7541144 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature