Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer.

ABSTRACT:

Background

The pan-cancer analysis has recently brought us into a novel level of cancer research. Nowadays, the Circular RNAs (circRNAs) is becoming increasingly important in the occurrence and progression of tumors. Nevertheless, the specific expression patterns and functions of circRNAs in the pan-cancer remains unclear. Here we aimed to explore the expression patterns and functions of circRNAs in pan-cancer.

Methods

We combined our microarray with seven circRNA arrays from the Gene Expression Omnibus (GEO) database and transcriptome profiles were acquired from The Cancer Genome Atlas (TCGA) database. A circRNA-miRNA-mRNA network was created and analyzed using multiple bioinformatic approaches including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enr

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7541145 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature