Temporal changes in the vaginal microbiota in self-samples and its association with persistent HPV16 infection and CIN2.

ABSTRACT:

Background

The vaginal microbiota has been reported to be associated with HPV infection and cervical cancer. This study was performed to compare the vaginal microbiota at two timepoints in women performing self-sampling and had a persistent or transient HPV16 infection. The women were tested for 12 high-risk HPV (hrHPV) types but only women with single type (HPV16) were included to reduce confounding variables.

Methods

In total 96 women were included in this study. Of these, 26 were single positive for HPV16 in the baseline test and HPV negative in the follow-up test and 38 were single positive for HPV16 in both tests and diagnosed with CIN2+ in histology. In addition, 32 women that were negative for all 12 HPV tested were included. The samples of vaginal fluid were analyzed

SUBMITTER: Berggrund M 

PROVIDER: S-EPMC7541248 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature