A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues.

ABSTRACT:

Background

Although considerable progress has been made towards annotating the noncoding portion of the human and mouse genomes, regulatory elements in other species, such as livestock, remain poorly characterized. This lack of functional annotation poses a substantial roadblock to agricultural research and diminishes the value of these species as model organisms. As active regulatory elements are typically characterized by chromatin accessibility, we implemented the Assay for Transposase Accessible Chromatin (ATAC-seq) to annotate and characterize regulatory elements in pigs and cattle, given a set of eight adult tissues.

Results

Overall, 306,304 and 273,594 active regulatory elements were identified in pig and cattle, respectively. 71,478 porcine and 47,454 bovine regulato

SUBMITTER: Halstead MM 

PROVIDER: S-EPMC7541309 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature