The Epilepsy-Related Protein PCDH19 Regulates Tonic Inhibition, GABA_AR Kinetics, and the Intrinsic Excitability of Hippocampal Neurons.

ABSTRACT: PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral deficits. We recently reported that PCDH19 binds the alpha subunits of GABA_A receptors (GABA_ARs), modulating their surface availability and miniature inhibitory postsynaptic currents (mIPSCs). Here, we investigated whether PCDH19 regulatory function on GABA_ARs extends to the extrasynaptic receptor pool that mediates tonic current. In fact, the latter shapes neuronal excitability and network properties at the base of information processing. By com

SUBMITTER: Serratto GM 

PROVIDER: S-EPMC7541378 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature