Interferon Therapy in Myelofibrosis: Systematic Review and Meta-analysis.

ABSTRACT:

Background

Myelofibrosis (MF) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by progressive bone marrow failure, increased risk of progression to acute myeloid leukemia, and constitutional symptoms. For over 3 decades, various formulations of interferon (IFN) have been used for the treatment of MF, with variable results, and the role of IFN in the treatment of MF is evolving.

Patients and methods

For this systematic review and meta-analysis, Medline and Embase via Ovid, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science were searched from inception through March 2019 for studies of pegylated IFN (peg-IFN) and non-peg-IFN in MF patients. The primary outcome of overall response rate was defined as a composite o

SUBMITTER: Bewersdorf JP 

PROVIDER: S-EPMC7541411 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature