Ontology highlight
ABSTRACT:
SUBMITTER: Teschendorff AE
PROVIDER: S-EPMC7541488 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Teschendorff Andrew E AE Wang Ning N
NPJ genomic medicine 20201007
Tissue-specific transcription factors are frequently inactivated in cancer. To fully dissect the heterogeneity of such tumor suppressor events requires single-cell resolution, yet this is challenging because of the high dropout rate. Here we propose a simple yet effective computational strategy called SCIRA to infer regulatory activity of tissue-specific transcription factors at single-cell resolution and use this tool to identify tumor suppressor events in single-cell RNA-Seq cancer studies. We ...[more]