Polygenic score for sleep duration. Association with cognition.

ABSTRACT:

Study objectives

Age-related changes in sleep include a reduction in total sleep time and a greater incidence of sleep disorders, and are also an integral part of neurodegenerations. In the present study, we aimed to: a) identify common genetic variants that may influence self-reported sleep duration, and b) examine the association between the identified genetic variants and performance in different cognitive domains.

Methods

A sample of 197 cognitively healthy participants, aged 20-80 years, mostly non-Hispanic Whites (69%), were selected from the Reference Abilities Neural Network and the Cognitive Reserve study. Each participant underwent an evaluation of sleep function and assessment of neuropsychological performance on global cognition and four different domains (memory

SUBMITTER: Tsapanou A 

PROVIDER: S-EPMC7541541 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature