Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection.

ABSTRACT: Pathogen-specific memory T cells (T_M) contribute to enhanced immune protection under conditions of reinfection, and their effective recruitment into a recall response relies, in part, on cues imparted by chemokines that coordinate their spatiotemporal positioning. An integrated perspective, however, needs to consider T_M as a potentially relevant chemokine source themselves. In this study, we employed a comprehensive transcriptional/translational profiling strategy to delineate the identities, expression patterns, and dynamic regulation of chemokines produced by murine pathogen-specific T_M CD8⁺T_M, and to a lesser extent CD4⁺T_M, are a prodigious source for six select chemokines (CCL1/3/4/5, CCL9/10, and XCL1) that c

SUBMITTER: Davenport B 

PROVIDER: S-EPMC7541577 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature