Ontology highlight
ABSTRACT:
SUBMITTER: Riviere P
PROVIDER: S-EPMC7541603 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Riviere Paul P Goodman Aaron M AM Okamura Ryosuke R Barkauskas Donald A DA Whitchurch Theresa J TJ Lee Suzanna S Khalid Noor N Collier Rachel R Mareboina Manvita M Frampton Garrett M GM Fabrizio David D Sharabi Andrew B AB Kato Shumei S Kurzrock Razelle R
Molecular cancer therapeutics 20200803 10
Higher tumor mutational burden (TMB) has been correlated with response to checkpoint blockade immunotherapy. However, it is unclear whether TMB independently serves as a prognostic biomarker for outcomes in immunotherapy-naïve patients. Here, we evaluated the relationship between TMB and overall survival in 1,415 immunotherapy-naïve patients with diverse advanced malignancies. TMB was studied both as a tiered variable (low ≤5 mutations/Mb, intermediate >5 and <20, high ≥20 and <50, and very high ...[more]