Risk of Breast Cancer Associated with Estrogen DNA Adduct Biomarker.

ABSTRACT:

Background

It is biologically plausible that genotoxic estrogens, namely estrogen DNA adducts (EDA), have a role in breast cancer development. Support comes from three prior studies that reported elevated concentrations of EDA relative to estrogen metabolites and conjugates (EDA:EMC) in women with breast cancer relative to control women.

Methods

In postmenopausal women in the Women's Health Initiative (WHI), EDA:EMC in 191 controls was compared with findings in 194 prediagnosis urine samples from breast cancer cases. EDA:EMC determinations were by mass spectrometry as previously described, and logistic regression was employed to estimate ORs.

Results

EDA:EMC did not differ in breast cancer cases compared with controls overall [0.93 (95% confidence interval, 0.71-1.23)

SUBMITTER: Reding KW 

PROVIDER: S-EPMC7541674 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature