A randomized controlled trial of amyloid positron emission tomography results disclosure in mild cognitive impairment.

ABSTRACT:

Introduction

Recent studies suggest that Alzheimer's disease (AD) biomarker disclosure has no discernable psychological impact on cognitively healthy persons. Far less is known about how such results affect symptomatic individuals and their caregivers.

Methods

Randomized controlled trial of 82 mild cognitive impairment (MCI) patient and caregiver dyads (total n = 164) to determine the effect of receiving amyloid positron emission tomography results on understanding of, and perceived efficacy to cope with, MCI over 52 weeks of follow-up.

Results

Gains in the primary outcomes were not consistently observed. Amyloid negative patients reported greater perceived ambiguity regarding MCI at follow-up, while moderate and sustained emotional distress was observed in patients,

SUBMITTER: Lingler JH 

PROVIDER: S-EPMC7541680 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature