Treatment of Advanced Melanoma in 2020 and Beyond.

ABSTRACT: The melanoma field has seen an unprecedented set of clinical advances over the past decade. Therapeutic efficacy for advanced or metastatic melanoma went from being one of the most poorly responsive to one of the more responsive. Perhaps most strikingly, the advances that transformed management of the disease are based upon modern mechanism-based therapeutic strategies. The targeted approaches that primarily suppress the BRAF oncoprotein pathway have a high predictability of efficacy although less optimal depth or durability of response. Immunotherapy is primarily based on blockade of one or two immune checkpoints and has a lower predictability of response but higher fractions of durable remissions. This article reviews the clinical progress in management of advanced melanoma and also disc

SUBMITTER: Jenkins RW 

PROVIDER: S-EPMC7541692 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature