Initiation, discontinuation, and restarting HIV pre-exposure prophylaxis: ongoing implementation strategies.

ABSTRACT: When used appropriately, pre-exposure prophylaxis (PrEP) substantially reduces the risk of HIV acquisition. Early implementation outcomes often suggest poor PrEP adherence and persistence; however, this intervention is time-limited and the need for PrEP fluctuates as risk behaviours change. In this Viewpoint we examine the current guidelines and early programmatic outcomes after starting, stopping, and restarting PrEP, and we review the implications of PrEP in relation to HIV testing algorithms. Guidelines suggest to discontinue PrEP when a person is no longer at risk for HIV, but effectively implementing this strategy requires support tools to make the decision of stopping and restarting PrEP that considers the complex relationship between risk perceptions and risk behaviours. Safely disc

SUBMITTER: Rutstein SE 

PROVIDER: S-EPMC7541752 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature