SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth.

ABSTRACT: Mechanisms regulating nuclear organization control fundamental cellular processes, including the cell and chromatin organization. Their disorganization, including aberrant nuclear architecture, has been often implicated in cellular transformation. Here, we identify Lamin A, among proteins essential for nuclear architecture, as SPANX (sperm protein associated with the nucleus on the X chromosome), a cancer testis antigen previously linked to invasive tumor phenotypes, interacting protein in melanoma. SPANX interaction with Lamin A was mapped to the immunoglobulin fold-like domain, a region critical for Lamin A function, which is often mutated in laminopathies. SPANX downregulation in melanoma cell lines perturbed nuclear organization, decreased cell viability, and promoted senescence-associ

SUBMITTER: Lazar I 

PROVIDER: S-EPMC7541784 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature