Quantitative evaluation of hepatic integrin α_vβ₃ expression by positron emission tomography imaging using ¹⁸F-FPP-RGD₂ in rats with non-alcoholic steatohepatitis.

ABSTRACT:

Background

Integrin α_vβ₃, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis. Recently, we reported that an RGD peptide positron emission tomography (PET) probe is useful as a predictor of hepatic fibrosis. Kinetic analysis of the RGD PET probe has been performed in tumours, but not in hepatic fibrosis. Therefore, we aimed to quantify hepatic integrin α_vβ₃ in a model of NASH by kinetic analysis using ¹⁸F-FPP-RGD₂, an integrin α_vβ₃ PET probe.

Methods

¹⁸F-FPP-RGD₂ PET/CT scans were performed in control and NASH rats. Tissue kinetic analyses were performed using a one-tissue, two-compar

SUBMITTER: Hiroyama S 

PROVIDER: S-EPMC7541810 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature