Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model.

ABSTRACT: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and govern disease progression are unclear. To gain insight into this biology, we interrogated the role of oxyguanine glycosylase 1 (OGG1), which repairs oxidized guanine 8-Oxo-2'-deoxyguanosine (8-OH-dG), in the pristane-induced mouse model of SLE. Ogg1^-/- mice showed increased influx of Ly6C^hi monocytes into the peritoneal cavity and enhanced IFN-driven gene expression in response to short-term exposure to pristane. Loss of Ogg1 was associated with increased auto-ant

SUBMITTER: Tumurkhuu G 

PROVIDER: S-EPMC7541920 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature