Genetic disorders and male infertility.

ABSTRACT:

Background

At present, one out of six couples is infertile, and in 50% of cases, infertility is attributed to male infertility factors. Genetic abnormalities are found in 10%-20% of patients showing severe spermatogenesis disorders, including non-obstructive azoospermia.

Methods

Literatures covering the relationship between male infertility and genetic disorders or chromosomal abnormalities were studied and summarized.

Main findings results

Genetic disorders, including Klinefelter syndrome, balanced reciprocal translocation, Robertsonian translocation, structural abnormalities in Y chromosome, XX male, azoospermic factor (AZF) deletions, and congenital bilateral absence of vas deferens were summarized and discussed from a practical point of view. Among them, understan

SUBMITTER: Kuroda S 

PROVIDER: S-EPMC7542010 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature