Masakari: visualization supported statistical analysis of genome segmentations.

ABSTRACT:

Background

In epigenetics, the change of the combination of histone modifications at the same genomic location during cell differentiation is of great interest for understanding the function of these modifications and their combinations. Besides analyzing them locally for individual genomic locations or globally using correlations between different cells types, intermediate level analyses of these changes are of interest. More specifically, the different distributions of these combinations for different cell types, respectively, are compared to gain new insights.

Results and discussion

We propose a new tool called 'Masakari' that allows segmenting genomes based on lists of ranges having a certain property, e.g., peaks describing histone modifications. It provides a graphical

SUBMITTER: Zeckzer D 

PROVIDER: S-EPMC7542120 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature