Coating Persistent Luminescence Nanoparticles With Hydrophilic Polymers for in vivo Imaging.

ABSTRACT: Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow in vivo imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(N-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely use

SUBMITTER: Liu J 

PROVIDER: S-EPMC7542242 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature