Yield and Utility of Germline Testing Following Tumor Sequencing in Patients With Cancer.

ABSTRACT:

Importance

Both germline genetic testing and tumor DNA sequencing are increasingly used in cancer care. The indications for testing and utility of these 2 tests differ, and guidelines recommend that germline analysis follow tumor sequencing in certain patients to determine whether particular variants are of somatic or germline origin. Broad clinical experience with such follow-up testing has not yet been thoroughly described.

Objective

To examine the yield and utility of germline testing following tumor DNA sequencing in a large, diverse patient population.

Design, setting, and participants

A retrospective cohort study examined germline testing through a laboratory supporting multiple academic and community clinics. Participants included 2023 patients with cancer who

SUBMITTER: Lincoln SE 

PROVIDER: S-EPMC7542302 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature